Editorial: Multi-omic data integration
نویسندگان
چکیده
منابع مشابه
Editorial: Multi-omic data integration
As researchers involved in molecular biology, we are witnessing tremendous paradigm changes in a time frame that becomes shorter and shorter. The epoch-making notion, originally put forward by the central dogma of biology (Crick, 1970), that there is a unidirectional process and a privileged level (genetic) of causality at which biological functions are determined, has already long and strongly...
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Rapid growth in size and complexity of biological data sets has led to the 'Big Data to Knowledge' challenge. We develop advanced data integration methods for multi-level analysis of genomic, transcriptomic, ribosomal profiling, proteomic and fluxomic data. First, we show that pairwise integration of primary omics data reveals regularities that tie cellular processes together in Escherichia col...
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Accurate prediction of disease risk is needed for implementing personalized medicine. Despite important advances in the assessment of genetic risk, our ability to predict disease risk based on information from the genome (e.g., SNPs) remains very limited. Owing to developments in high-throughput technologies integrated omic profiles are becoming increasingly available. These data holds informat...
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Synechococcus sp. PCC 7002 is a fast-growing cyanobacterium which flourishes in freshwater and marine environments, owing to its ability to tolerate high light intensity and a wide range of salinities. Harnessing the properties of cyanobacteria and understanding their metabolic efficiency has become an imperative goal in recent years owing to their potential to serve as biocatalysts for the pro...
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The representation, integration, and interpretation of omic data is a complex task, in particular considering the huge amount of information that is daily produced in molecular biology laboratories all around the world. The reason is that sequencing data regarding expression profiles, methylation patterns, and chromatin domains is difficult to harmonize in a systems biology view, since genome b...
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ژورنال
عنوان ژورنال: Frontiers in Cell and Developmental Biology
سال: 2015
ISSN: 2296-634X
DOI: 10.3389/fcell.2015.00046